Amytracker 680

Amytracker 680 is our red fluorescent optotracer molecule for labeling protein aggregates with repetitive arrangement of β-sheets. It labels Aβ plaques and neurofibrillary tangles in tissue sections with AD pathology and α-synuclein aggregates in tissue sections with PD pathology. Specifically, Amytracker 680 has been used to study amyloid formation during abnormal coagulation, Lewy body formation in a seeding based neuronal model, accumulation of misfolded proteins in the nucleolus and intracerebral formation of Aβ plaques using multiphoton microscopy.

As all our optotracers, Amytracker 680 is exceptionally photostable and fluorogenic. When bound to a target, Amytracker 680 can be imaged using fluorescence microscopy and spectral information can be acquired using a fluorescence spectrophotometer. Use recommended filter sets as well as excitation- and emission wavelengths according to Table 1.

Amytracker 680 is available as a 1 mg/ml solution in volumes ranging from 10 - 200 µL (see volumes and prices in the list below). As our standard solvent, we use ultrapure water. Please contact us for custom options.

DISCLAIMER: Amytracker are exceptionally stable and there is no direct requirement of handling or storing them in the dark or refrigerated. However, evaporation of aqueous solvent can occur upon opening/handling. Please make sure to close the container carefully, spin down liquid and use up small volumes quickly.