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Exciting breakthrough in cellular imaging!

Small protein aggregates (below 450 nm) are highly toxic as they are able to penetrate the cell membrane.
Their small size makes these aggregates especially hard to study.

💡 With Amytracker, however, you can finally see them! 💡

Michael J. Morten and colleagues came up with a new approach that involves using Amytracker 630 and super-resolution microscopy to resolve aggregates involved in neurodegenerative disorders.
In their experiments, Amytracker 630 performed much better than conventional staining methods, such as Thioflavin! 🏅

"We show that Amytracker 630 (AT630), a commercial aggregate-activated fluorophore, has outstanding photophysical properties that enable super-resolution imaging of α-synuclein, tau, and amyloid-β aggregates, achieving ∼4 nm precision"

📚 Want to learn more? Read the full article here and here.

🔬 Imaging of cell-penetrating aggregate species in HEK cells (Live super-resolution imaging by SMLM.) AmyT 630 (red), Proteasome foci (green). Typical foci-aggregate colocalizations are shown in the zoomed-in images. (white scale bars: 2 μm l and 200 nm) (Fig. 3C) (CC BY 4)

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