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Amyloids - The Dark Matter of Biology

Amyloids Amytracker™

Amyloids - The Dark Matter of Biology

Under some conditions, peptides or proteins may convert from their soluble forms into unsoluble highly ordered fibrillar aggregates. These aggregates may cause disease through various mechanisms. Prominent examples of aggregating peptides related to neurodegenerative diseases are Amyloid β peptides which play an important role in Alzheimer's disease and aggregating α-synuclein which is found in Lewy bodies that are a hallmark of Parkinson's disease and some forms of dementia. Multiple variants...

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Amytracker™ for amyloid staining

Amyloids Amytracker™

Amytracker™ for amyloid staining

Amyloid detection has been notoriously difficult since current methods are either laborious, toxic and/or tend to detect mature fibrils but not protofibrils or premature aggregates. Amytracker™ are fluorescent tracer molecules binding to amyloids with high sensitivity. Amytracker™ have been shown to bind to prefibrillar states of amyloids and might therefore help to detect and investigate earlier prepathological states of amyloid diseases. As Amytracker™ are fluorescent only when bound to their...

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