As functional aspects of amyloids as well as the dynamic processes involving amyloid formation and amyloid toxicity are of growing interest many researchers are interested to study these processes in living cells. Non-invasive techniques like fluorescence microsopy have been perfected in recent years for the study of living cells. Unfortunately, few non-toxic fluoresecent dyes with high affinity to amyloids exist. Amytracker™ have been shown to be non-toxic fluorescent probes binding amyloid fibrils reliably. Moreover, Amytracker™ will cross the cell membrane readily requiring only minimal incubation times.