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In vivo amyloid staining

Amytracker™ in vivo Mulitphoton Microscopy

In vivo amyloid staining

Intravital imaging is allowing researchers to capture images of biological processes in live animals. It has become an advanced tool to study the progression of Alzheimer's disease in transgenic mice. In vivo imaging using two-photon microscopy is an advantageous technique for observing the animal tissues and organs at high resolution. Amytracker™ are suitable for in vivo studies since our probes are non-toxic, cross the blood-brain barrier and stain fibrous deposits...

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Live Cell Imaging

Amytracker™ Life Cell Imaging

Live Cell Imaging

As functional aspects of amyloids as well as the dynamic processes involving amyloid formation and amyloid toxicity are of growing interest many researchers are interested to study these processes in living cells. Non-invasive techniques like fluorescence microsopy have been perfected in recent years for the study of living cells. Unfortunately, few non-toxic fluoresecent dyes with high affinity to amyloids exist. Amytracker™ have been shown to be non-toxic fluorescent probes binding amyloid fibrils...

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Amyloids - The Dark Matter of Biology

Amyloids Amytracker™

Amyloids - The Dark Matter of Biology

Under some conditions, peptides or proteins may convert from their soluble forms into unsoluble highly ordered fibrillar aggregates. These aggregates may cause disease through various mechanisms. Prominent examples of aggregating peptides related to neurodegenerative diseases are Amyloid β peptides which play an important role in Alzheimer's disease and aggregating α-synuclein which is found in Lewy bodies that are a hallmark of Parkinson's disease and some forms of dementia. Multiple variants...

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How can Amytracker distinguish different forms of Amyloids?

Amytracker™ Analytical Imaging Spectral Imaging

How can Amytracker distinguish different forms of Amyloids?

Amytracker™ are a fluorescent tracer molecules. A flexible backbone structure allows Amytracker™ to align with its target. Small changes in target structure lead to small changes in Amytracker™ backbone conformation and thus to a slight shift in emission which might be picked up choosing bandpass filters or spectral imaging. Amytracker™ has been used to differentiate between β-amyloid and tau aggregates in AD tissue sections or different strains of prion protein....

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Amytracker™ for amyloid staining

Amyloids Amytracker™

Amytracker™ for amyloid staining

Amyloid detection has been notoriously difficult since current methods are either laborious, toxic and/or tend to detect mature fibrils but not protofibrils or premature aggregates. Amytracker™ are fluorescent tracer molecules binding to amyloids with high sensitivity. Amytracker™ have been shown to bind to prefibrillar states of amyloids and might therefore help to detect and investigate earlier prepathological states of amyloid diseases. As Amytracker™ are fluorescent only when bound to their...

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