How is Amytracker™ better than Thioflavin?


When Amytracker™ are not bound to a target, they exhibit an extremely low background fluorescence. Amytracker™ have also ben shown to neither accelerate nor inhibit amyloid formation when used in recommended (substochoimetric) concentrations. Therefore, Amytracker™ are suitable for fibrillation assays and spectrophotometric detection.
Amytracker™ have been shown to identify pre-fibrillar non-thioflavinophilic assemblies during in vitro fibrillation of Aβ peptides, insulin, lysozyme and prion protein with significantly reduced lag-phase compared to Thioflavin.

Older Post Newer Post

Leave a comment

Please note, comments must be approved before they are published