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How and Where is Amytracker™ binding?


All Amytracker™ molecules are designed to interact with the same binding site on the amyloid oligomer. Competition assays have shown that Amytracker™ competes for the congo red binding site but show much higher affinity. In essence the binding cavity and binding mode of Amytracker™ is is dictated by a groove lined with repetitive positive charged side-chains. The detection of prefibrillar species appears dependent on 8 repetitive β sheets, composed of a minimum of eight in-register parallel-β-strands.

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