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Does Amytracker™ bind unspecifically?

We tested a wide range of human tissues and didn't observe unspecific staining in most cell types. Positive Amytracker™ staining was obtained in Paneth cell granules in the intestine stained and the binding target in these cells is yet unclear. Due to the high sensitivity of Amytracker™ towards amyloids, and its ability to detect Congo Red negative and non-thioflavinic assemblies, Amytracker™ might serve as an interesting tool to study functional amyloids in different species.

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