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Anomalous fibrin amyloid formation

Atypical Amyloids Functional Amyloids

Anomalous fibrin amyloid formation

Lipopolysaccharides (LPS) from the Gram-negative cell envelope can be shed from dormant bacteria or from continual bacteria entry into the blood and serve to contribute to the chronic inflammation. The presence of highly substoichiometric amounts of LPS from Gram-negative bacteria caused fibrinogen clotting to lead to the formation of an amyloid form of fibrin. The teams around Prof. Douglas B. Kell from the University of Manchester and Prof. Etheresia Pretorius from the...

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Plasma clots from type 2 diabetics contain amyloids

Atypical Amyloids Type-2-Diabetes

Plasma clots from type 2 diabetics contain amyloids

Type 2 diabetes (T2D) is a progressive condition marked by resistance towards the blood-sugar regulating hormone insulin. Recently, T2D is become recognized as an inflammatory condition which is often accompanied by cardiovascular complications. The teams around Prof. Etheresia Pretorius from Stellenbosh University and Prof. Douglas B. Kell from the University of Manchester investigated blood clot formation from plasma of diabetic patients. Using advanced confocal microscopy and Structured Illumination Superresolution Microscopy...

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