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Amytracker can be used for intracerebral Multiphoton Microscopy

Amytracker can be used for intracerebral Multiphoton Microscopy

A fluorescent probe of the same type as Amytracker has been shown to pass the blood brain barrier labeled Amyloid-β deposits without toxicity.
Calvo-Rodriguez, M. et al. In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. Acta Neuropathol. Commun. 7, 171 (2019).

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The clue to detect Multiple Systems Atrophy?

The clue to detect Multiple Systems Atrophy?

A fluorescent tracer molecule like Amytracker™ has been used to detect α-synuclein aggregates in cerebrospinal fluid.
Shahnawaz, Mohammad, Abhisek Mukherjee, Sandra Pritzkow, Nicolas Mendez, Prakruti Rabadia, Xiangan Liu, Bo Hu, et al. 2020. Nature 578 (7794): 273–77.

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Anomalous fibrin amyloid formation

Anomalous fibrin amyloid formation

Amytracker has been used to show presence of amyloids in blood clots.
Pretorius, E., Page, M. J., Hendricks, L., Nkosi, N. B., Benson, S. R., & Kell, D. B. (2018). Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: Assessment with novel Amytracker fluorescent tracer molecules. Journal of the Royal Society Interface, 15(139). 

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Amyloids in Type-2 diabetes

Amyloids in Type-2 diabetes

Blood clots from patients with Type-2 diabetes contain more amyloids than blood clots from healthy people.
Pretorius, E., Page, M. J., Engelbrecht, L., Ellis, G. C., & Kell, D. B. (2017). Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains. Cardiovascular Diabetology, 16(1), 1–14.

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Advanced Imaging

Advanced Imaging

Researchers from Linköping University have used Hyperspectral Imaging and Fluorescence Lifetime Imaging for investigating misfolded proteins.
Nyström, S., Bäck, M., Nilsson, K. P. R., & Hammarström, P. (2017). Imaging amyloid tissues stained with luminescent conjugated oligothiophenes by hyperspectral confocal microscopy and fluorescence lifetime imaging. Journal of Visualized Experiments, 2017(128)

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Protein engineering for better PET radioligands

Protein engineering for better PET radioligands

Amytracker was used to investigate transport of engineered radioligands across the blood brain barrier.
Sehlin, D., Fang, X. T., Meier, S. R., Jansson, M., & Syvänen, S. (2017). Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β. Scientific Reports, 7(1), 1–9.

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Artifical Amyloids

Artifical Amyloids

Researchers use artificial amyloids to cause a functional knockdown of growth factors.

Gallardo, R., Ramakers, M., De Smet, F., Claes, F., Khodaparast, L., Khodaparast, L. and Rousseau, F. (2016). De novo design of a biologically active amyloid. Science, 354(6313), aah4949.


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