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Plasma clots from type 2 diabetics contain amyloids

Atypical Amyloids Type-2-Diabetes

Type 2 diabetes (T2D) is a progressive condition marked by resistance towards the blood-sugar regulating hormone insulin. Recently, T2D is become recognized as an inflammatory condition which is often accompanied by cardiovascular complications. The teams around Prof. Etheresia Pretorius from Stellenbosh University and Prof. Douglas B. Kell from the University of Manchester investigated blood clot formation from plasma of diabetic patients. Using advanced confocal microscopy and Structured Illumination Superresolution Microscopy (SR-SIM), the authors found that plasma clots from diabetic patients contain signifcant amounts of amyloid hinting towards an inflammatory cue for the occurence of cardiovascular symptoms in T2D.

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