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Artifical Amyloids

Functional Amyloids

Artifical Amyloids

A team of scientists around Frederic Rousseau from Switch Laboratory at KU Leuven have designed a biologically active amyloid from a peptide sequence occurring in vascular endothelial growth factor 2 (VEGFR2). The peptide, which the researchers named vascin forms artificial amyloids. The results show, however, that vascin amyloids are not inherently toxic but that the emergence of amyloid toxicity is dependent on the biological context. When vascin oligomers are applied...

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Protein engineering for better PET radioligands

Immunohistochemistry PET

Protein engineering for better PET radioligands

An approved method for visualization of Amyloid β (Aβ) plaques in patients suffering from Alzheimer's disease is Positron Emission Tomography (PET). This method requires a radiolabeled amyloid ligand. A frequently used molecule is Pittsburgh Compound B (PIB) which is a derivative of Thioflavin T. Radiolabeled PIB is well-suited to visualize insoluble Aβ plaques and has been used for differential diagnosis of AD. However, the PIB signal, giving an estimate of...

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Anomalous fibrin amyloid formation

Atypical Amyloids Functional Amyloids

Anomalous fibrin amyloid formation

Lipopolysaccharides (LPS) from the Gram-negative cell envelope can be shed from dormant bacteria or from continual bacteria entry into the blood and serve to contribute to the chronic inflammation. The presence of highly substoichiometric amounts of LPS from Gram-negative bacteria caused fibrinogen clotting to lead to the formation of an amyloid form of fibrin. The teams around Prof. Douglas B. Kell from the University of Manchester and Prof. Etheresia Pretorius from the...

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Plasma clots from type 2 diabetics contain amyloids

Atypical Amyloids Type-2-Diabetes

Plasma clots from type 2 diabetics contain amyloids

Type 2 diabetes (T2D) is a progressive condition marked by resistance towards the blood-sugar regulating hormone insulin. Recently, T2D is become recognized as an inflammatory condition which is often accompanied by cardiovascular complications. The teams around Prof. Etheresia Pretorius from Stellenbosh University and Prof. Douglas B. Kell from the University of Manchester investigated blood clot formation from plasma of diabetic patients. Using advanced confocal microscopy and Structured Illumination Superresolution Microscopy...

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HIS and FLIM and LCOs

Amytracker™ FLIM Spectral Imaging

HIS and FLIM and LCOs

In a new study in the Journal of visualized experiments, the team around Prof. Peter Nilsson and Prof. Per Hammarström from Linköpings University describe how luminescent conjugated oligothiophenes (LCOs) can be used with Hyperspectral Imaging (HIS) and Fluorescence Lifetime Imaging (FLIM) to detect amyloid species. In a practical approach, the authors highlight caveats of LCO staining and give valuable advice on troubleshooting. <p><a title="Imaging Amyloid Tissues Stained with Luminescent Conjugated...

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